Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study
Date
2024-03-28Author
Mukunya, David
Oguttu, Faith
Nambozo, Brendah
Nantale, Ritah
Makoko, Brian Tonny
Napyo, Agnes
Tumuhamye, Josephine
Wani, Solomon
Auma, Prossy
Atim, Ketty
Nahurira, Doreck
Okello, Dedan
Wamulugwa, Joan
Ssegawa, Lawrence
Wandabwa, Julius
Kiguli, Sarah
Chebet, Martin
Musaba, Milton W.
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Show full item recordAbstract
Over two million children and adolescents suffer from chronic kidney disease globally. Early childhood
insults such as birth asphyxia could be risk factors for chronic kidney disease in later life. Our study aimed to assess
renal function among children aged two to four years, born to women with obstructed labour.
We followed up 144 children aged two to four years, born to women with obstructed labor at Mbale
regional referral hospital in Eastern Uganda. We used serum creatinine to calculate estimated glomerular filtration rate
(eGFR) using the Schwartz formula. We defined decreased renal function as eGFR less than 90 ml/min/1.73m2
.
The mean age of the children was 2.8 years, standard deviation (SD) of 0.4 years. Majority of the children were
male (96/144: 66.7%). The mean umbilical lactate level at birth among the study participants was 8.9 mmol/L with a
standard deviation (SD) of 5.0. eGFR of the children ranged from 55 to 163 ml/min/1.73m2
, mean 85.8±SD 15.9. Nearly
one third of the children (45/144) had normal eGFR (>90 ml/Min/1.73m2
), two thirds (97/144) had a mild decrease of
eGFR (60–89 ml/Min/1.73m2
), and only two children had a moderate decrease of eGFR (<60 ml/Min/1.73m2
). Overall
incidence of reduced eGFR was 68.8% [(99/144): 95% CI (60.6 to 75.9)].
We observed a high incidence of reduced renal function among children born to women with
obstructed labour. We recommend routine follow up of children born to women with obstructed labour and add our
voices to those calling for improved intra-partum and peripartum care.