Kebba, AnthonyAtwine, DianaMwebaze, RaymondKityo, CissyNakityo, RoseMulenyi, Peter2021-04-212021-04-212004-07-05Kebba, A., Atwine, D., Mwebaze, R., Kityo, C., Nakityo, R. and Peter, M., 2002. Therapeutic responses to AZT+ 3TC+ EFV in advanced antiretroviral naive HIV type 1-infected Ugandan patients. AIDS research and human retroviruses, 18(16), pp.1181-1187.0889-22291931-8405http://hdl.handle.net/20.500.12280/2680Convenient, non-food-dependent dosing, low tablet volume, and relatively low cost have made nonnucleoside reverse transcriptase inhibitors a first choice for both clinicians and patients in Uganda. Concerns exist as to their efficacy in patients with viral loads (VL) above 100,000 copies/ml, a feature common to about 75% of HIV-1-infected patients presenting at the Joint Clinical Research Center (JCRC) in Uganda. Furthermore, there are few data on the response to such therapy of non-B subtypes, A and D, predominant in Uganda. Presented here is a retrospective analysis of therapeutic responses in 11 antiretroviral (ARV) naïve HIV-1-infected Ugandan patients who had been initiated on zidovudine (AZT), lamivudine (3TC), and efavirenz (EFV). Laboratory assessments subsequent to initiation of ARV therapy, done at 11.6 ± 3.9 weeks and 30.6 ± 5.9 weeks, showed 88.9 and 71.4% patients achieved undetectable viral load, respectively. Virological suppression to below detection occurred in 85.7% of patients at 11.6 weeks despite baseline VL ≥ 100,000 copies/ml. At 31 weeks there was a median increment of +183 cells/mm3 in CD4+ T lymphocytes. These findings reflect significant efficacy in the use of AZT + 3TC + EFV in advanced ARV naive non-B subtype HIV-1-infected patients. The therapeutic responses were comparable to those previously described in the western world.enTherapeutic responsesPatientsAntiretroviralNaive HIV type 1UgandaArticle