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The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood [ISRCTN32849447]
(Society for Clinical Trials, 2007)
Helminths have profound effects on the immune response, allowing long-term survival of parasites with minimal damage to the host. Some of these effects “spill-over”, altering responses to non-helminth antigens or allergens. ...
Associations Between Maternal Helminth and Malaria Infections in Pregnancy and Clinical Malaria in the Offspring: A Birth Cohort in Entebbe, Uganda
(Oxford University Press on behalf of the Infectious Diseases Society of America, 2013)
Helminth and malaria coinfections are common in the tropics. We investigated the hypothesis
that prenatal exposure to these parasites might influence susceptibility to malaria in childhood.
Methods. In a birth cohort of ...
Parasite infection is associated with Kaposi’s sarcoma associated herpesvirus (KSHV) in Ugandan women
(BioMed Central, 2011)
Background: Immune modulation by parasites may influence susceptibility to bacteria and viruses. We examined
the association between current parasite infections, HIV and syphilis (measured in blood or stool samples ...
Plasmodium falciparum parasitaemia and clinical malaria among school children living in a high transmission setting in western Kenya
(BioMed Central, 2016)
Background: Malaria among school children is increasingly receiving attention, yet the burden of malaria in this age group is poorly defined. This study presents data on malaria morbidity among school children in Bungoma ...
Assessing the external validity of a randomized controlled trial of anthelminthics in mothers and their children in Entebbe, Uganda
(BioMed Central, 2014)
The ‘external validity’ of randomized controlled trials is an important measure of quality, but is often
not formally assessed. Trials concerning mass drug administration for helminth control are likely to guide public
health ...
Effect of Praziquantel Treatment during Pregnancy on Cytokine Responses to Schistosome Antigens: Results of a Randomized, Placebo-Controlled Trial
(Infectious Diseases Society of America, 2008)
Praziquantel treatment of schistosomiasis boosts antischistosome responses, with type 2 helper T cell bias that may contribute to immunologically mediated killing and to protection against reinfection. Praziquantel treatment ...
Anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema: randomised-controlled trial results
(John Wiley & Sons A/S, 2011)
Background: Allergy is commoner in developed than in developing countries. Chronic worm infections show inverse associations with allergy, and prenatal exposures may be critical to allergy risk.
Objective: To determine ...
Effects of Deworming during Pregnancy on Maternal and Perinatal Outcomes in Entebbe, Uganda: A Randomized Controlled Trial
(Infectious Diseases Society of America, 2010)
Helminth infections during pregnancy may be associated with adverse outcomes, including maternal anemia, low birth weight, and perinatal mortality. Deworming during pregnancy has therefore been strongly advocated, but its ...
Maternal hookworm modifies risk factors for childhood eczema: results from a birth cohort in Uganda
(Pediatric Allergy and Immunology, 2014)
Background: Worms may protect against allergy. Early-life worm exposure may be critical, but this has not been fully investigated.
Objectives: To investigate whether worms in pregnancy and in early childhood are associated ...
Association between malaria exposure and Kaposi’s sarcoma-associated herpes virus seropositivity in Uganda
(John Wiley & Sons Ltd., 2015)
Objective: Unlike other herpes viruses, Kaposi’s sarcoma-associated herpes virus (KSHV) is not ubiquitous worldwide and is most prevalent in sub-Saharan Africa. The reasons for this are unclear. As part of a wider investigation ...