Journal Articles (Science)

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Browsing Journal Articles (Science) by Author "Govule, Philip"

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    Prevalence and drug susceptibility of isolates of urinary tract infections among febrile under-fives in Nsambya Hospital, Uganda
    (Open Science Journal of Clinical Medicine, 2015) Katongole, Simon Peter; Ocokoru, Christine; Onzima, Robert Anguyo DDM; Govule, Philip
    Background: Urinary tract infections remain a silent cause of morbidity and complications among under-fives due to its nonspecific presentation and incapacity of most health facilities in developing countries to diagnose it. Earlier studies present different prevalence of urinary tract infections among children. This study aimed to document prevalence and drug susceptibility patterns of isolates of bacterial urinary tract infections among under-fives in Nsambya hospital, Uganda. Methodology: We conducted a descriptive cross-sectional survey among 302 under-fives who presented in paediatric ambulatory care department of Nsambya hospital with fever (axillary temperature of >37.5°C or by history); and with no history of antibiotic therapy within three days preceding hospital visit. Midstream urine samples collected using bag and bottle collection (depending on age of child) were subjected to culture. We further subjected culture-positive urine samples to systematic bacteriologic and biochemical tests in order to identify the organisms in the colonies before performing drug susceptibility tests. Results: We found urinary tract infection prevalent in 26.8% of the under-fives. Bacterial isolates responsible for the infections were Proteus (39.5%), Escherichia coli (32.1%), Staphylococcus aureus (14.8%), Klebsiella spp. (6.2%), Staphylococcus haemolyticus (2.5%), Staphylococcus intermedius (2.5%), Citrobacter (1.2%) and Morganella (1.2%) in that order. The pathogens exhibited high-level of resistance to commonly used antibiotics like Cotrimoxazole, Amoxicillin, Nalidixic Acid, Nitrofurantoin, Gentamicin, Erythromycin, Chloramphenicol, Ampicillin, Ciproflaxin, Tetracycline and Azithromicin while the isolates showed no resistance to pharmaco-enhanced Amoxicillin and oral Cefatoxime. Conclusion: Prevalence of UTI among febrile under-fives in Nsambya hospital is higher than reports from majority of earlier studies. Similarly, the commonest bacterial isolates associated with UTI among under-fives in Nsambya hospital deviates from most studies in developing countries that majorly report Escherichia coli as the leading cause of UTI in this age category. The observed resistance patterns associated with common antibiotics in our study are in line with the current changing patterns of microbial-antibiotic resistance threatening not only the developing world but the entire glob.