Factors associated with uptake of isoniazid preventive therapy among children under 5 years tuberculosis contacts in greater Kibaale, Uganda
Date
2022-03-31
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Science and Education Publishing
Abstract
Isoniazid Preventive Therapy (IPT) is a chemoprophylaxis which reduces the risk of the first episode of
TB occurring in people exposed to an infection or with latent infection and the risk of a recurrent episode of TB.
WHO recommends isoniazid taken at a daily dose of 5 mg/kg (maximum 300 mg) for at least six months. In Uganda,
only 16% of 15957 children contacts of smear-positive TB index cases are on preventive treatment. The objective of
this study was to assess factors associated with uptake of isoniazid preventive therapy among children under 5 years’
tuberculosis contacts in Greater Kibaale. An analytical cross-sectional study design utilizing both quantitative and
qualitative methods was conducted among 207 children under 5 years’ tuberculosis contacts. They were recruited
using convenience sampling methods. The caregiver of the children completed a structured questionnaire in English
and translated into Lunyoro. Data was single-entered and analyzed using SPSS version 22. Bivariate, univariate and
multivariate Logistic regression analysis methods were used to identify factors associated with uptake of isoniazid
preventive. Of the 207 participants, the uptake IPT was low at 36.7%. Being in the age group of 35-44 years
(AOR=15.856, 95% CI: 11.568-27.115), being married, AOR=17.867, 95% CI: 4.631-215.769), p=.008) being
separated (AOR=4.4.35, 95% CI; 1.056-6.530, p=0.047), having a monthly income of 40,000-100,000 shillings
(AOR=9.917, 95% CI: 6.380-15.450, p=.000), finding it easy to talk to other people about TB problem AOR=.012,
95% CI: .004-.303, p=.007), not screening for TB (AOR=0.391, 95% CI: .242-.791, p=.000) and receiving
continuous counselling (AOR=0.004, 95% CI: .001-.142, p=.002) were independently associated with uptake
of isoniazid preventive. Conclusively, the level of uptake of IPT was low. Contact screening seems a good entry
point for delivery of Isoniazid Preventive Therapy to at-risk children when routinely practised as recommended by
WHO.
Description
Keywords
Isoniazid Preventive Therapy (IPT), Tuberculosis (TB), Health care, Health care - barriers, Health care - facilitators, Quality of care