Effects and Factors Associated With Indoor Residual Spraying With Actellic 300 CS on Malaria Morbidity in Lira District, Northern Uganda

dc.contributor.authorTugume, Abdulaziz
dc.contributor.authorMuneza, Fiston
dc.contributor.authorOporia, Frederick
dc.contributor.authorKiconco, Arthur
dc.contributor.authorKihembo, Christine
dc.contributor.authorKisakye, Angela Nakanwagi
dc.contributor.authorNsubuga, Peter
dc.contributor.authorSekimpi, Deogratias
dc.contributor.authorYeka, Adoke
dc.date.accessioned2022-05-19T22:25:40Z
dc.date.available2022-05-19T22:25:40Z
dc.date.issued2019
dc.description.abstractBackground Indoor residual spraying (IRS) with Actellic 300 CS was conducted in Lira District between July and August 2016. No formal assessment has been conducted to estimate the effect of spraying with Actellic 300 CS on malaria morbidity in the Ugandan settings. This study assessed malaria morbidity trends before and after IRS with Actellic 300 CS in Lira District in Northern Uganda. Methods The study employed a mixed methods design. Malaria morbidity records from four health facilities were reviewed, focusing on 6 months before and after the IRS intervention. The outcome of interest was malaria morbidity defined as; proportion of outpatient attendance due to total malaria, proportion of outpatient attendance due to confirmed malaria and proportion of malaria case numbers confirmed by microscopy or rapid diagnostic test. Since malaria morbidity was based on count data, an ordinary Poisson regression model was used to obtain percentage point change (pp) in monthly malaria cases before and after IRS. A household survey was also conducted in 159 households to determine IRS coverage and factors associated with spraying. A modified Poisson regression model was fitted to determine factors associated with household spray status. Results The proportion of outpatient attendance due to malaria dropped from 18.7% before spraying to 15.1% after IRS. The proportion of outpatient attendance due to confirmed malaria also dropped from 5.1% before spraying to 4.0% after the IRS intervention. There was a decreasing trend in malaria test positivity rate (TPR) for every unit increase in month after spraying. The decreasing trend in TPR was more prominent 5–6 months after the IRS intervention (Adj. pp = − 0.60, P-value = 0.015; Adj. pp = − 1.19, P-value < 0.001). The IRS coverage was estimated at 89.3%. Households of respondents who were formally employed or owned any form of business were more likely to be unsprayed; (APR = 5.81, CI 2.72–12.68); (APR = 3.84, CI 1.20–12.31), respectively. Conclusion Coverage of IRS with Actellic 300 CS was high and was associated with a significant decline in malaria related morbidity 6 months after spraying.en_US
dc.identifier.citationTugume, A., Muneza, F., Oporia, F., Kiconco, A., Kihembo, C., Kisakye, A.N., Nsubuga, P., Deogratias, S. and Yeka, A., 2019. Effects and factors associated with indoor residual spraying with Actellic 300 CS on malaria morbidity in Lira District, Northern Uganda. Malaria Journal, 18(1), pp.1-10.en_US
dc.identifier.issn1475-2875
dc.identifier.urihttp://hdl.handle.net/20.500.12280/2998
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofseriesMalaria Journal;18(1)
dc.subjectMalariaen_US
dc.subjectIndoor residual spraying (IRS)en_US
dc.subjectMorbidity trends Percentage point (pp)en_US
dc.subjectTest positivity rate (TPR)en_US
dc.titleEffects and Factors Associated With Indoor Residual Spraying With Actellic 300 CS on Malaria Morbidity in Lira District, Northern Ugandaen_US
dc.typeArticleen_US

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