Risk Factors for Seropositivity to Kaposi Sarcoma–Associated Herpesvirus Among Children in Uganda

dc.contributor.authorWakeham, Katie
dc.contributor.authorWebb, Emily L.
dc.contributor.authorSebina, Ismail
dc.contributor.authorNalwoga, Angela
dc.contributor.authorMuhangi, Lawrence
dc.contributor.authorMiley, Wendell
dc.contributor.authorJohnston, Thomas
dc.contributor.authorNdibazza, Juliet
dc.contributor.authorWhitby, Denise
dc.contributor.authorNewton, Robert
dc.contributor.authorElliott, Alison M
dc.date.accessioned2018-07-26T09:29:52Z
dc.date.available2018-07-26T09:29:52Z
dc.date.issued2013
dc.description.abstractBackground: Determinants of Kaposi sarcoma–associated herpesvirus (KSHV) seropositivity among children living in sub-Saharan African populations where infection is endemic are not well understood. Local environmental factors, including other infectious agents, may be key. Methods: Within the context of a well-characterized birth cohort, we examined associations between various factors and antibodies against KSHV, measured in stored plasma samples from 1823 mother–child pairs in Entebbe, Uganda. Results: Seroprevalence increased with increasing age of the child (P = 0.0003) and was higher among those with KSHV seropositive mothers than in those without (12% vs 9%; odds ratio: 1.4, 95% confidence interval: 1.1 to 2.0). It was also higher among children with HIV infection (29% vs 10%; odds ratio: 3.1, 95% confidence interval: 1.2 to 8.3) or malaria parasitemia (30% vs 10%; odds ratio: 4.1, 95% confidence interval: 2.4 to 7.0) than in children without. These associations were not explained by socioeconomic status. Conclusions: The finding that KSHV serostatus is associated with malaria parasitemia in children is novel. In a country endemic for KSHV, malaria may be a cofactor for KSHV infection or reactivation among children.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12280/553
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofseriesAcquir Immune Defic Syndr;
dc.subjectKaposi sarcomaen_US
dc.subjectHIVen_US
dc.subjectChildrenen_US
dc.subjectSub-Saharan Africaen_US
dc.subjectKaposi sarcoma-associated herpesvirusen_US
dc.titleRisk Factors for Seropositivity to Kaposi Sarcoma–Associated Herpesvirus Among Children in Ugandaen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Ndibazza_Health_Article_2013_C.pdf
Size:
116.52 KB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: