Risk Factors for Seropositivity to Kaposi Sarcoma–Associated Herpesvirus Among Children in Uganda
dc.contributor.author | Wakeham, Katie | |
dc.contributor.author | Webb, Emily L. | |
dc.contributor.author | Sebina, Ismail | |
dc.contributor.author | Nalwoga, Angela | |
dc.contributor.author | Muhangi, Lawrence | |
dc.contributor.author | Miley, Wendell | |
dc.contributor.author | Johnston, Thomas | |
dc.contributor.author | Ndibazza, Juliet | |
dc.contributor.author | Whitby, Denise | |
dc.contributor.author | Newton, Robert | |
dc.contributor.author | Elliott, Alison M | |
dc.date.accessioned | 2018-07-26T09:29:52Z | |
dc.date.available | 2018-07-26T09:29:52Z | |
dc.date.issued | 2013 | |
dc.description.abstract | Background: Determinants of Kaposi sarcoma–associated herpesvirus (KSHV) seropositivity among children living in sub-Saharan African populations where infection is endemic are not well understood. Local environmental factors, including other infectious agents, may be key. Methods: Within the context of a well-characterized birth cohort, we examined associations between various factors and antibodies against KSHV, measured in stored plasma samples from 1823 mother–child pairs in Entebbe, Uganda. Results: Seroprevalence increased with increasing age of the child (P = 0.0003) and was higher among those with KSHV seropositive mothers than in those without (12% vs 9%; odds ratio: 1.4, 95% confidence interval: 1.1 to 2.0). It was also higher among children with HIV infection (29% vs 10%; odds ratio: 3.1, 95% confidence interval: 1.2 to 8.3) or malaria parasitemia (30% vs 10%; odds ratio: 4.1, 95% confidence interval: 2.4 to 7.0) than in children without. These associations were not explained by socioeconomic status. Conclusions: The finding that KSHV serostatus is associated with malaria parasitemia in children is novel. In a country endemic for KSHV, malaria may be a cofactor for KSHV infection or reactivation among children. | en_US |
dc.identifier.uri | http://hdl.handle.net/20.500.12280/553 | |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.relation.ispartofseries | Acquir Immune Defic Syndr; | |
dc.subject | Kaposi sarcoma | en_US |
dc.subject | HIV | en_US |
dc.subject | Children | en_US |
dc.subject | Sub-Saharan Africa | en_US |
dc.subject | Kaposi sarcoma-associated herpesvirus | en_US |
dc.title | Risk Factors for Seropositivity to Kaposi Sarcoma–Associated Herpesvirus Among Children in Uganda | en_US |
dc.type | Article | en_US |