Factors associated with severity and anatomical distribution of diabetic foot ulcer in Uganda: a multicenter cross-sectional study

dc.contributor.authorBienfait Mumbere, Vahwere
dc.contributor.authorSsebuufu, Robinson
dc.contributor.authorNamatovu, Alice
dc.contributor.authorKyamanywa, Patrick
dc.contributor.authorNtulume, Ibrahim
dc.contributor.authorMugwano, Isaac
dc.contributor.authorPius, Theophilus
dc.contributor.authorSikakulya Katembo, Franck
dc.contributor.authorOkedi, Francis Xaviour
dc.contributor.authorMulumba, Yusuf
dc.contributor.authorJorge, Soria
dc.contributor.authorAgaba, Gidio
dc.contributor.authorNasinyama, George William
dc.date.accessioned2024-04-26T11:42:37Z
dc.date.available2024-04-26T11:42:37Z
dc.date.issued2023-03-10
dc.description.abstractDiabetic foot ulcer (DFU) is a devastating complication of diabetes mellitus (DM) that is associated with increased mortality, morbidity, amputation rate and economic burden. This study aimed at identifying the anatomical distribution and factors associated with severity of DFU in Uganda. This was a multicenter cross-sectional study conducted in seven selected referral hospitals in Uganda. A total of 117 patients with DFU were enrolled in this study between November 2021 and January 2022. Descriptive analysis and modified Poisson regression analysis were performed at 95% confidence interval; factors with p-value<0.2 at bivariate analysis were considered for multivariate analysis. The right foot was affected in 47.9% (n=56) of patients, 44.4% (n=52) had the DFU on the plantar region of the foot and 47.9% (n=56) had an ulcer of >5 cm in diameter. The majority (50.4%, n=59) of patients had one ulcer. 59.8% (n=69) had severe DFU, 61.5% (n=72) were female and 76.9% had uncontrolled blood sugar. The mean age in years was 57.5 (standard deviation 15.2 years). Primary (p=0.011) and secondary (p<0.001) school educational levels, moderate (p=0.003) and severe visual loss (p=0.011), 2 ulcers on one foot (p=0.011), and eating vegetables regularly were protective against developing severe DFU (p=0.03). Severity of DFU was 3.4 and 2.7 times more prevalent in patients with mild and moderate neuropathies (p<0.01), respectively. Also, severity was 1.5 and 2.5 higher in patients with DFU of 5–10 cm (p=0.047) and in those with >10 cm diameter (p=0.002), respectively. Most DFU were located on the right foot and on the plantar region of the foot. The anatomical location was not associated with DFU severity. Neuropathies and ulcers of >5 cm diameter were associated with severe DFU but primary and secondary school education level and eating vegetables were protective. Early management of the precipitating factors is important to reduce the burden of DFU.en_US
dc.identifier.issn1471-2458
dc.identifier.urihttps://doi.org/10.1186/s12889-023-15383-7
dc.identifier.urihttp://hdl.handle.net/20.500.12280/3128
dc.language.isoenen_US
dc.publisherBMC Springer Natureen_US
dc.relation.ispartofseriesBMC Public Health;23, Article number: 463 (2023)
dc.subjectDiabetic foot ulceren_US
dc.subjectSeverityen_US
dc.subjectUgandaen_US
dc.titleFactors associated with severity and anatomical distribution of diabetic foot ulcer in Uganda: a multicenter cross-sectional studyen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Kyamanywa-Article-MotherKevin-2023-SeverityAnatomical.pdf
Size:
1.49 MB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.85 KB
Format:
Item-specific license agreed upon to submission
Description:

Collections