Viral Load Detection Using Dried Blood Spots in a Cohort of HIV-1- Infected Children in Uganda: Correlations with Clinical and Immunological Criteria for Treatment Failure
Date
2014-07
Authors
Costenaro Paola
Lundin Rebecca
Petrara Raffaella Maria
Penazzato Martina
Massavon William
Kizito Susan
Nabachwa Monica Sandra
Musoke Nannyonga Maria
Namisi Charles
Morelli Erika
Journal Title
Journal ISSN
Volume Title
Publisher
AMER SOC MICROBIOLOGY , 1752 N ST NW, WASHINGTON, USA, DC, 20036-2904
Abstract
Correlations between clinical/immunological treatment failure and viral load (VL) detected by dried blood spot (DBS) sampling were explored in HIV-1-infected children in Uganda. Of 104 children on combined antiretroviral treatment (cART), 12.5% experienced clinical and/or immunological failure, while 28.8%, 44.2%, and 26.9% had VLs of <1,000, 1,000 to 5,000, and >5,000 copies/ml, respectively. Clinical/immunological failure poorly predicted virological failure.
Description
Keywords
Viral load detection, Dried blood spots, HIV-1-infected children, Uganda, Clinical, Immunological, Treatment failure
Citation
Costenaro, P., Lundin, R., Petrara, M.R., Penazzato, M., Massavon, W., Kizito, S., Nabachwa, S.M., Musoke, M.N., Namisi, C., Morelli, E. and Bilardi, D., 2014. Viral load detection using dried blood spots in a cohort of HIV-1-infected children in Uganda: correlations with clinical and immunological criteria for treatment failure. Journal of clinical microbiology, 52(7), pp.2665-2667.