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Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood: A Randomised Controlled Trial
(Uganda Martyrs University, 2012)
Background: Helminth infections may modulate immune responses to unrelated pathogens and allergens; these effects may commence prenatally. We addressed the hypothesis that anthelminthic treatment in pregnancy and early ...
Participation in Clinical Research Could Modify Background Risk for Trial Outcome Measures
(2014)
Data on HIV incidence and retention are needed to inform study design of efficacy trials. However, the selection criteria and interventions during an actual clinical trial could
reduce HIV incidence and thus affect the ...
Effect of Single-Dose Anthelmintic Treatment During Pregnancy on an Infant’s Response to Immunisation and on Susceptibility to Infectious Diseases in Infancy: a Randomised, Double-Blind, Placebo-Controlled Trial
(2011)
Helminth infections aff ect the human immune response. We investigated whether prenatal exposure to and treatment of maternal helminth infections aff ects development of an infant’s immune response toimmunisations and ...
Effects of Maternal and Infant Co-infections, and of Maternal Immunization, on the Infant Response to BCG and Tetanus Immunization
(2012)
Some vaccines show poor efficacy in tropical countries. Within a birth cohort in Uganda, we investigatedfactors that might influence responses to BCG and tetanus immunisation. Whole blood assay responsesto crude culture ...
Associations Between Maternal Helminth and Malaria Infections in Pregnancy and Clinical Malaria in the Offspring: A Birth Cohort in Entebbe, Uganda
(Oxford University Press on behalf of the Infectious Diseases Society of America, 2013)
Helminth and malaria coinfections are common in the tropics. We investigated the hypothesis
that prenatal exposure to these parasites might influence susceptibility to malaria in childhood.
Methods. In a birth cohort of ...
Parasite infection is associated with Kaposi’s sarcoma associated herpesvirus (KSHV) in Ugandan women
(BioMed Central, 2011)
Background: Immune modulation by parasites may influence susceptibility to bacteria and viruses. We examined
the association between current parasite infections, HIV and syphilis (measured in blood or stool samples ...
Plasmodium falciparum parasitaemia and clinical malaria among school children living in a high transmission setting in western Kenya
(BioMed Central, 2016)
Background: Malaria among school children is increasingly receiving attention, yet the burden of malaria in this age group is poorly defined. This study presents data on malaria morbidity among school children in Bungoma ...
Assessing the external validity of a randomized controlled trial of anthelminthics in mothers and their children in Entebbe, Uganda
(BioMed Central, 2014)
The ‘external validity’ of randomized controlled trials is an important measure of quality, but is often
not formally assessed. Trials concerning mass drug administration for helminth control are likely to guide public
health ...
Anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema: randomised-controlled trial results
(John Wiley & Sons A/S, 2011)
Background: Allergy is commoner in developed than in developing countries. Chronic worm infections show inverse associations with allergy, and prenatal exposures may be critical to allergy risk.
Objective: To determine ...
Effects of Deworming during Pregnancy on Maternal and Perinatal Outcomes in Entebbe, Uganda: A Randomized Controlled Trial
(Infectious Diseases Society of America, 2010)
Helminth infections during pregnancy may be associated with adverse outcomes, including maternal anemia, low birth weight, and perinatal mortality. Deworming during pregnancy has therefore been strongly advocated, but its ...