Browsing by Author "Kayiira Anthony"

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Impact of Genital Chlamydia Trachomatis Infection on Reproductive Outcomes Among Infertile Women Undergoing Tubal Flushing
(BioMed Central Ltd, 2019-12-12) Kayiira Anthony; Zaake Daniel; Lwetabe Webba Michael; Sekweyama Peter
Background: The impact of current C. trachomatis on clinical pregnancy and live birth rates among women undergoing tubal flushing is largely unknown. This study aimed to investigate whether current female genital C. trachomatis infection affects the chance of achieving a clinical pregnancy and a live birth, among infertile women undergoing tubal flushing, at a fertility centre in Uganda. Methods: A retrospective Cohort study at a peri-urban fertility centre. A total of 253 eligible women with tubal factor infertility, who underwent tubal flushing, were enrolled and categorised according to their exposure to current genital C. trachomatis infection. These women were followed up for a period of 12 months, with the primary outcome measure being clinical pregnancy and live birth. Secondary outcome measures included pregnancy loss and procedural related adverse events. Results: Exposure to current genital C. trachomatis infection reduced chance of clinical pregnancy (adjusted relative risk 0.42; 95% confidence interval, 0.18–0.96) and a live birth (adjusted relative risk 0.37; 95% confidence interval, 0.14–0.95) after tubal flushing. Women with current C. trachomatis infection had an increased risk of adverse events (adjusted relative risk, 1.20; 95% confidence interval, 1.08–1.34). However, current C. trachomatis infection did not affect the risk of spontaneous abortion and ectopic pregnancy. Conclusion: Current genital C. trachomatis infection in women with tubal factor infertility, undergoing tubal flushing, lowers their chance of pregnancy and live birth.
Perceptions, Expectations and Challenges Among Men During in Vitro Fertilization Treatment in a Low Resource Setting: A Qualitative Study
(Springer Nature, 2019-07-04) Zaake Daniel; Kayiira Anthony; Namagembe Imelda
Introduction: Partner support is very important in alleviating the burden of infertility related stress and although understudied, partner coping patterns also play a key role in the other partner’s ability to cope with the infertility experience which eventually affects treatment outcomes. Very few studies more so in a low to middle income setting, explore the psychological and social aspects of infertility in men. There is a need for a deeper understanding into men’s perceptions, expectations and challenges of fertility treatment in our low resource setting. Objective: To explore men’s perceptions, expectations, challenges and experiences during IVF treatment among men in a low resource setting. Methods: A qualitative research design was utilised. The study was conducted at life sure fertility and gynaecology centre. The study participants were men participating in the IVF cycles. They were selected purposefully by maximum variation sampling. All the interviews took place on the day of enrolment for treatment and inductive content analysis was used to draw meaning from the transcripts. Ethical approval for the study will be sought from Nsambya Hospital IRB/REC. Results: Seven major themes arose, and these included: (1) Societal influence on IVF treatment experience; (2) Social support during IVF treatment; (3) Feeling insignificant; (4) Financial burden; (5) IVF as an emotional bridge; (6) Inadequate sensitization; (7) Fear of treatment failure. Conclusion: Men’s experiences during IVF treatment were negatively affected by the society’s perceptions of IVF treatment and infertility, cost of treatment, perceived men’s involvement and insufficient knowledge about the IVF process. However, spouse and friends’ support helped with coping and the IVF treatment experience strengthened emotional bonds
Prevalence of vitamin D deficiency and its association with adverse obstetric outcomes among pregnant women in Uganda: a cross- sectional study
(PubMed Central, 2025-01-09) Reverzani Cristina; Zaake Daniel; Nansubuga Faridah; Ssempewo Herman; Manirakiza Leonard; Kayiira Anthony; Tumwine Gilbert
The study was conducted on 351 pregnant women aged ≥18 years who consented to participate in the study, who had a single intrauterine pregnancy and a gestational age greater than 26 weeks, and who delivered at St. Francis Hospital, Nsambya. We excluded pregnant women admitted to the hospital longer than 1 week before delivery; pregnant women with self-reported pre-existing kidney diseases, liver diseases, or gut or malabsorption disorders and pregnant women with severe pregnancy-unrelated comorbidities requiring intensive care unit admission before delivery. Maternal venous blood was collected at admission, and serum 25-hydroxy-vitamin D (25(OH)D) was measured by an electrochemiluminescence binding assay. Maternal sociodemographic characteristics and obstetric-medical factors, and adverse maternal and foetal outcomes were captured by using a data collection form. The data were analysed by logistic regression analysis at the univariate, bivariate and multivariate levels. The prevalence of vitamin D deficiency, defined as a serum 25(OH)D concentration less than 20 ng/mL, was 40.2%. This was seen more among the Muslims (OR 2.4, 95% CI 1.33 to 4.43, p value 0.004), members of the Banyankore tribe (OR 2.1, 95% CI 1.02 to 4.36, p value 0.043) and primigravidae (OR 0.6 for women with parity of 1–4 compared with primigravidity, 95% CI 0.36 to 0.94, p value 0.028). Among adverse maternal outcomes, vitamin D deficiency was associated with hypertensive disorders in pregnancy (OR 2.4, 95% CI 1.16 to 4.10, p value <0.001), in particular gestational hypertension (OR 2.2, 95% CI 1.21 to 4.94, p value 0.014), and pre-eclampsia/eclampsia/haemolysis, elevated liver enzymes and low platelets syndrome (OR 2.9, 95% CI 1.45 to 6.08, p value 0.003), with increased preterm birth (OR of 4.0, 95% CI 1.78 to 10.84, p value<0.001) and with delivery of babies with low birth weight (OR 4.2, 95% CI 2.63 to 13.62, p value 0.001). The study found a high prevalence (40.2%) of vitamin D deficiency among pregnant women delivering at St. Francis Hospital, Nsambya. Additionally, vitamin D deficiency was linked with adverse maternal and foetal outcomes such as hypertensive disorders in pregnancy, preterm birth and low birth weight.
Prevalence, regional distribution, and determinants of infertility in Uganda between 2006 and 2016: analysis of three demographic and health surveys
(2024) Zaake Daniel; Amongin Dinah; Beňová Lenka; Kiwanuka N. Suzanne; Nalwadda K Christine; Nakafeero Mary; Riese Sara; Kayiira Anthony; Asefa Anteneh
Low- and middle-income countries, particularly in the African region in-country distribution and determinants of infertility are understudied. In this study, we aimed to estimate the prevalence, regional distribution, and determinants of infertility in Uganda to inform programming. We estimated the prevalence of primary and secondary infertility among women aged 20-49 years using data from the three rounds of the Uganda Demographic and Health Survey 2006, 2011, and 2016, and compared the differences across geographic regions. We pooled data sets for all three years and conducted logistic regression to identify factors associated with infertility. We included 16,537 women aged 20-49 years for analysis of primary infertility and 12,628 for secondary infertility. The overall prevalence of infertility (pooled across the three surveys was 6.4%. The prevalence of primary infertility was 1.4% (95% Confidence interval, CI=1.0-1.8), 0.7% (95% CI=0.5-1.0) and 0.8% (95% CI=0.6-1.0) in 2006, 2011 and 2016, respectively. The prevalence of secondary infertility was 7.4% (95% CI=6.5-8.4), 6.9% (95% CI=5.9-8.0) and 7.1% (95% CI=6.4-7.9) in 2006, 2011, and 2016 respectively. The prevalence of primary infertility was similar across regions. Secondary infertility was highest in the Central (7.9%, 95% CI= 6.1-10.3, in 2016) and Northern regions (7.4%, 95% CI=6.1-8.9, in 2016). In all survey years, women with higher education had lower odds of secondary infertility compared to women with no education (adjusted odds ratio, aOR=0.54, 95% CI=0.35-0.83; P < 0.001). Our results suggest that the prevalence of primary infertility is similar across regions, whereas secondary infertility varies by region, with higher prevalence in Central and Northern regions. More research is required to understand the drivers behind the variation of secondary infertility across regions to inform policy and decision making
Translation and cultural adaptation of the FertiQoL questionnaire into Luganda: a comprehensive report
(African Journals Online (AJOL), 2025-06-23) Makumbi Douglas; Kayiira Anthony; Tumwine Gilbert; Byaruhanga N Romano; Zaake Daniel
The FertiQoL questionnaire is globally recognized to assess quality of life (QoL) among infertile individuals. To make this tool accessible to Luganda-speaking populations in Uganda, it was necessary to translate the questionnaire into Luganda, ensuring cultural relevance and linguistic accuracy. The translation process followed a rigorous forward-backward translation methodology. Two separate translations were performed by native Luganda speakers. The unified version was translated back into English to find discrepancies. Experts validated the translated questionnaire, showing high agreement on most items, confirming its cultural and linguistic suitability. The translated questionnaire was pilot tested on 20 infertile patients at St. Francis Nsambya Hospital to assess the clarity and comprehensibility. The pilot study indicated that most items were understood, with no significant difficulties reported. However, four items required minor modifications. The Luganda FertiQoL questionnaire effectively measures the quality of life in individuals experiencing infertility in Uganda. Le questionnaire FertiQoL est mondialement reconnu pour évaluer la qualité de vie (QdV) des personnes infertiles. Afin de rendre cet outil accessible aux populations lugandaphones en Ouganda, il a été nécessaire de le traduire en luganda, garantissant ainsi sa pertinence culturelle et sa précision linguistique. Le processus de traduction a suivi une méthodologie rigoureuse de traduction aller-retour. Deux traductions distinctes ont été réalisées par des locuteurs natifs du luganda. La version unifiée a été retraduite en anglais afin d'identifier les divergences. Des experts ont validé le questionnaire traduit, montrant une forte concordance sur la plupart des items, confirmant ainsi sa pertinence culturelle et linguistique. Le questionnaire traduit a été testé auprès de 20 patients infertiles à l'hôpital St. Francis Nsambya afin d'évaluer sa clarté et sa compréhensibilité. L'étude pilote a montré que la plupart des items étaient compris, sans difficulté majeure signalée. Cependant, quatre items ont nécessité des modifications mineures. Le questionnaire FertiQoL en luganda mesure efficacement la qualité de vie des personnes souffrant d'infertilité en Ouganda.